I do have the experience but if you attach a debugger to a non-Denuvo or a Denuvo game, then have any hacker/modder come into the room and look at the code, manipulate it or inject new code, they won’t notice the difference or face any obstacles.

Modder here. Denuvo has absolutely no effect on modding. Steam DRM checks the integrity of the executable and also crashes on breakpoints. That said, it’s easy to remove with Steamless. Memory hacks work fine.

Edit: However, Space Marine 2 is going to use EAC, which is a kernel-level anti-cheat which prevents any modding short of utilizing or creating private hacks that may involve rogue system drivers.