I’m using phosh, which I believe has some gnome components.

I can see there’s a quick setting for adjusting screen scaling and options for large text. There’s also an option for a screen reader in the accessibility options but it doesn’t seem to do anything now that I’m trying it, maybe I have to download some TTS program to make it work.

I have a oneplus 6T with postmarketOS and it works pretty well.

There’s also a native desktop mode for grapheneos now, you can activate it in dev options

You can set obtanium up with a github user account to increase the rate limits in case you didn’t know. Here’s an explanation