In Super Robot Wars A Portable, there is a scenario boss that can join you later and when you manage to Ace him(get 50 kills and you get a unique ability for him) he gets ridiculously bulky the less health he has. That sounds helpful but that ability carries over back into his NPC Boss form in NG+ and I’ve heard it soft-locks the game.
Only way to avoid it is to know that information and don’t give him kills.
Far Cry 5. You can do everything in an attack helicopter.
“Shhh, quiet we need to sneak in undetected - stay close”
Soon as I can call in a helicopter close by, jump in and hover above escort NPC.
Destroy everything easily when combat is allowed.