Hi so saw a post last week about this and as I was having this issue decided to investigate. I found that every time I double tapped my select hero key bind to center the camera on my hero (which is a lot), it was as if I was tabbing out of the client because I had to click with the mouse on the game to regain controls as key binds would not register. This morning I found that there are two settings with overlap and after changing these settings the problem is solved. The first setting is in hotkeys->advanced there is the ‘Double Tap Ability to Self Cast’ option. Then, in the options menu top left, there is another option, ‘Double Tap Ability to Self Cast’. I found that one of the options was active, while the other was not. After activating both options to be on, the issue is no longer present. One of these options maybe should be removed because redundancy and chance of this negative interaction. Hope this helps!