With every start of Emacs 29, native comp starts compiling the files cl-loaddefs.el and tramp-loaddefs.el, but I can’t find corresponding *.eln files in (all) native-lisp directories. (Native compiling other (internal & extra) packages works, it is not an issue with access rights.)

What is the use of that behavior?

I could disable that native jit compiling, by putting following line in my early-init.el

(setq native-comp-jit-compilation-deny-list '(".*-loaddefs.el.gz"))

Would that break some facilities within Emacs, if I do so?