There is definitely exceptions. Though guitar instrumentals don’t do it for me, even though I generally listen to the rock/metal genre.

But for example I really like violin covers by this one artist/youtuber of movie and game soundtracks (especially the Zelda games). But that’s some of the only instrumental music I listen to and only when I’m in a specific mood.

And even there I think nostalgia is doing most of the heavy lifting for me enjoying the songs.