Main line story and optional romance quest are acceptable.

I’m not a romantic dude… AT ALL so for me my knowledge is very limited:

Tidus X Yuna - Final Fantasy X

Shepard x Jack - Mass Effect 2 (I actually adore this one, Jack is deceptively cute)

The… Warden? (Forgot the name) X Morrigan - Dragon Age Origins (She is so much fun to hang out with, I would legitimately fall for her irl)

What do you think about my picks? What are yours?