Be careful and keep a backup, I’ve read so many stories of Apple deleting people music randomly.

without being pwned

How do you know?

All of them except uBlock Origin are in Arkenfox “Do not bother” extension list: https://github.com/arkenfox/user.js/wiki/4.1-Extensions#-dont-bother

It does not. Domain based blocking does not work with youtube.

Your link event says it:

Some ads may […] be served through the same domain as the website, making them harder to block without blocking the website itself.

There is no point in using a proxy for this, because of https it won’t be able to block more than with DNS blocking. Maybe a tiny bit more if you set up mitm but that’s really not worth it.