I was playing the 2016 version of Master of Orion, and it’s a perfectly fine game, something akin to Civilization in space, it’s just not nearly as complex or interesting as Stellaris. Stellaris has created the ultimate space strategy game, and keeps adding new mechanics and features. I don’t really see why anyone would need to make a space strategy game again.
I can’t speak for the entire genre, but I can speak for games that have ruined genres for me.
GTA San Andreas… Every GTA that came after I haven’t enjoyed.
The Original Modern Warfare. Haven’t enjoyed or played a Call of Duty since.
PS2/Xbox era of Madden and NCAA; This honestly may be the best answer to this thread, since every Madden fan has begged them to go back to expanding the franchise mode along with bringing back college football. There are YouTube channels devoted to trashing Madden due to them not reaching the peak of the PS2/Xbox era. I have an Xbox original purely for the old Madden and NCAA football titles.