My first thoughts areMalignance + Anivia/ Kassadin(Whenever you damage an enemy champion with your Ultimate, burn the ground beneath them for 3 seconds, dealing 60 (+6% AP) magic damage every second and reducing their Magic Resistance by (6-12 [level scaling]) for as long as they are on the burning ground.)

6 Mini baron ZZ Rot + Trick2G on Udyr or Nasus (I can already see the YouTube content)

Zac, Kayn, maybe Rammus and Reksai being nerfed early in the season because they will be some of the few junglers who still have S tier ganks

There will definetly some weird support item abused. Some new support picks who can utilize the new upgrades super well (for example Brand got strong in support because his passive procced the gold generation multiple times, we will see similar synergies between support item and champ). Also, I’m waiting for the current iteration on how to abuse the support item outside of the support role.

Karma with Cryptbloom?Passive - Life From Death: Whenever you get a takedown on an enemy champion within 3 seconds of damaging them, create a healing nova on their location that heals allies for 50 (+50% AP). 60 second cooldown.Maybe not busted, but seems fun

Mordekaiser is gonna love the new Riftmaker, Akali is gonna hate it probablyVoid Corruption: For each second in combat with enemy champions, deal 2% bonus damage (max 10%). At maximum strength, gain 10% (melee) / 6% (ranged) Omnivamp.Omnivamp only at max stacks, but with higher AOE/ pet healing

Teemo + Liandry’s TormentTeemo is gonna love that Liandrys is now no more mana item, he can use the HP really well in top lane. I think it might put him back to his old levels of strength from s6-7 where he was sitting at ~53% winrate for most of the patches. Also great for rumble, I guessYes, there was Demonic Embrace but it sucked that it was not a mythic

KSante/ Sion with stasis in teamfights???

Ezreal and Kaisa mains are probably already looking at which item combos they can abuse

There will be probably a lot more, but I’m out of time, will maybe update later. What’s your predictions?