What do you consider the biggest letdowns, missed opportunities, falls from grace, bad decisions etc in the industries history?

Could be your personal example.

My first thoughts (slightly obvious choices): Silent Hills cancellation

Big publishers pushing out talent and great franchises losing quality (Mass Effect and Dead Space?)

Great game franchises kept alive without the original talent, (silent hill? Halo?).

(I started thinking about this considering the potential future of arkane, and what redfall and Bethesda may mean for their future)