Darksiders basically changes genre with every game. I’d say it’s the definitive answer to this.

Fire Emblem changes secondary mechanics and storytelling so often that it’s led to a fanbase that doesn’t agree on much of anything.

Guild Wars 2’s only real commonalities with GW1 are the world and horizontal progression.

Assassin’s Creed became a poor man’s Witcher 3.

Diablo changed drastically between entries.

Shining has run the gamut of first person dungeon crawlers, strategy RPGs, and action RPGs.