1. Gimp to batch edit pictures in a script (I know about ImageMagick but still)
2. Excel to change stuff in excel files quickly (I know about python modules but it’s so complicated to use)
3. Proprietary VPN software like Cisco AnyConnect, I want to automate the login when I boot, but they don’t let me

Just from the top of my head.

I love programs like freecad despite the really hard/unintuitive gui. 95% of all the modelling i need to do (as an amateur) can be done easily in a python script.

The finishing touches like adding filets and chamfers are the annoying part were gui is easier, due to the way edges are referenced.

Likewise at work, we have to produce a lot of regular reports in excel. All done via python / sql.